Contents

5 Diphtheria

5.7 Expected responses and adverse events following immunisation (AEFI)

Despite the widespread use of diphtheria toxoid, the 1994 Institute of Medicine review of vaccine reactions did not identify any reaction for which the evidence favoured or established a causal relationship with diphtheria toxoid.23 However, local and systemic reactions do occur with diphtheria toxoid-containing vaccine, especially when the infant vaccine is used in older children and adults.

See also sections 14.7 and 19.7 for expected responses and adverse events following immunisation with DTaP-IPV-HepB/Hib, DTaP-IPV, Tdap and Td.