The usual general contraindications to immunisation apply to HAV vaccine (see section 1.4). Administration of HAV vaccine should be delayed in individuals suffering from acute severe febrile illness. HAV vaccine should not be administered to people with a history of a severe reaction to a prior dose of HAV vaccine or to a vaccine component.
The safety of HAV vaccine during pregnancy and while breastfeeding has not been determined. However, because HAV vaccine is produced from inactivated HAV, the risk to the developing fetus and infant is expected to be extremely low. Therefore, the risk associated with vaccination during pregnancy and while breastfeeding should be weighed against the risk of HAV. As a precaution, HAV vaccines should be used during pregnancy and while breastfeeding only when clearly needed, such as when travelling to a country where HAV is endemic.
In individuals with an impaired immune system, adequate anti-HAV antibody titres may not be obtained after a single dose.